| Bioactivity | BTD is a selective transient receptor potential canonical 5 (TRPC5) activator. BTD can be used for the research of neurological disease[1]. |
| Target | EC50:1.4 μM (fluorometric microwell Ca2+ influx analyses); 1.3 μM (in whole cell patch clamp experiments); 20.6 μM (TRPM8-expressing HEK293 cells). |
| Invitro | BTD 可以激活 TRPC5，EC50 值分别为 1.4 μM（荧光微孔 Ca2+分析）和 1.3 μM（在全细胞膜片钳实验中）[1]。BTD 可以激活表达 TRPM8 的 HEK293 细胞，EC50 值为 20.6 μM[1]。BTD 可以激活由 TRPC5 及其近亲 TRPC1 或 TRPC4 组成的异聚通道复合体[1]。 |
| Name | BTD |
| CAS | 896684-04-1 |
| Formula | C24H33N3O4S |
| Molar Mass | 459.60 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Beckmann H,et al. A benzothiadiazine derivative and methylprednisolone are novel and selective activators of transient receptor potential canonical 5 (TRPC5) channels. Cell Calcium. 2017;66:10-18. |