BRPF1B/TRIM24-IN-1_product_DataBase

Bioactivity	BRPF1B/TRIM24-IN-1 (compound 34) is a potent TRIM24/BRPF1/BRPF2 inhibitor, with IC50 values of 0.43, 0.34, 1.75 μM, respectively. BRPF1B/TRIM24-IN-1 binds the TRIM24 bromodomain with a KD of 222 nM and has a KD for the BRPF1 bromodomain of 137 nM and for BRD1 of 1130 nM[1].
Invitro	BRPF1B/TRIM24-IN-1 (compound 34) 在乳腺癌细胞系 MCF-7 中没有表现出明显的细胞毒性。BRPF1B/TRIM24-IN-1 对一组癌细胞系 (MM1S、RCH-ACH、JJN3、RKO) 具有适度的细胞毒性 (GI50 > 10 μM)[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> BRPF1B/TRIM24-IN-1 相关抗体:
CAS	1242907-48-7
Formula	C24H25N3O7S
Molar Mass	499.54
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Bennett J, et al. Discovery of a Chemical Tool Inhibitor Targeting the Bromodomains of TRIM24 and BRPF. J Med Chem. 2016 Feb 25;59(4):1642-7.

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