Bioactivity | BRD4 ligand-Linker Conjugate 1 TFA (compound 106-1) is a target protein ligand-linker conjugate that can be used in the synthesis of PROTACs[1][2]. |
Name | BRD4 ligand-Linker Conjugate 1 TFA |
Formula | C30H31ClF3N7O2 |
Molar Mass | 614.06 |
Appearance | 粘稠液体 |
Transport | Room temperature in continental US; may vary elsewhere. |
Storage | 4°C, stored under nitrogen, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture) |
Reference | [1]. Sun D, et al. Evaluation of the Small-molecule BRD4 Degrader CFT-2718 in Small-cell Lung Cancer and Pancreatic Cancer Models. Mol Cancer Ther. 2021 Aug;20(8):1367-1377. [2]. Phillips AJ, et al. Preparation of bromodomain targeting degronimers for target protein degradation. World Intellectual Property Organization, WO2017197056 A1. 2017-11-16. |