| Bioactivity | BRD4 Inhibitor-28 (Compound 18) is an orally active BRD4 Inhibitor. BRD4 Inhibitor-28 inhibits BRD40-BD1, BRD40-BD2 with IC50s of 15, 55 nM. BRD4 Inhibitor-28 also inhibits BRD2-BD1, BRD3-BD1, BRDT-BD1 with IC50s of 19, 25, 68 nM. BRD4 Inhibitor-28 has anti-melanoma activity[1]. |
| Target | 15, 55, 19, 25, 68 nM (BRD40-BD1, BRD40-BD2, BRD2-BD1, BRD3-BD1, BRDT-BD1BRD2-BD1, BRD3-BD1, BRDT-BD1) |
| Name | BRD4 Inhibitor-28 |
| CAS | 2468960-80-5 |
| Formula | C23H21N3O3 |
| Molar Mass | 387.43 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Horai Y, et al. Discovery of a potent, orally available tricyclic derivative as a novel BRD4 inhibitor for melanoma. Bioorg Med Chem. 2023 Aug 26;93:117461. |
BRD4 Inhibitor-28
CAS: 2468960-80-5 F: C23H21N3O3 W: 387.43
BRD4 Inhibitor-28 (Compound 18) is an orally active BRD4 Inhibitor. BRD4 Inhibitor-28 inhibits BRD40-BD1, BRD40-BD2 with
Data collection：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.