| Bioactivity | BRD4 Inhibitor-25 is a BRD4 inhibitor with IC50s of 0.82 μM, 1.94 μM for BD1 and BD2 domains of BRD4. BRD4 Inhibitor-25 induces apoptotic and autophagy cell death in ovarian cancer cells. BRD4 Inhibitor-25 can be used in the research of cancers, cardiovascular, neuromuscular and inflammatory disorders. |
| Invitro | BRD4 Inhibitor-25 (化合物 11a) 抑制 OC 细胞系 (SKOV-3、OVCAR-3、SW626、ES-2 和 A2780) 的细胞增殖[1]。BRD4 Inhibitor-25 (当用过量的半胱氨酸处理时) 促进中等水平的 NO 释放 (10.587 μM)[1]。BRD4 Inhibitor-25 (1 和 2 μM，24 小时) 诱导 SKOV-3 细胞凋亡和自噬[1]。BRD4 Inhibitor-25 (2 μM，24 小时) 抑制自噬体和溶酶体融合，从而阻断 SKOV-3 细胞中的自噬通量[1]。 Cell Viability Assay[1] Cell Line: |
| In Vivo | BRD4 Inhibitor-25 (化合物 11a，30 mg/kg，腹腔注射) 抑制 SKOV-3 皮下异种移植模型中的肿瘤生长[1]。 Animal Model: |
| Name | BRD4 Inhibitor-25 |
| Formula | C29H27N5O6S |
| Molar Mass | 573.62 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zhang Y, et al. Design, synthesis and anti-ovarian cancer activities of thieno[2,3-d]pyrimidine based chimeric BRD4 inhibitor/nitric oxide-donator. Eur J Med Chem. 2022 Nov 29;246:114970. |