BRD4 Inhibitor-18_product_DataBase

Bioactivity	BRD4 Inhibitor-18 is a highly potent BRD4 inhibitor with an IC50 value of 110 nM. BRD4 Inhibitor-18 has a hydrophobic acetylcyclopentanyl side chain. BRD4 Inhibitor-18 can significantly suppress the proliferation of MV-4-11 cells with high BRD4 level. BRD4 Inhibitor-18 has apoptosis-promoting and G0/G1 cycle-arresting activity[1].
Invitro	BRD4 Inhibitor-18 (compound 13f) (0-10 μM; 72 hours) can suppress the proliferation of HL-60 and MV-41 cells[1].BRD4 Inhibitor-18 (0.5 and 5 μM; 12 hours) significantly arrests MV-4-11 cells in G1 phase in a dose-dependent manner[1].BRD4 Inhibitor-18 (0.5 and 5 μM; 12 hours) effectively induces apoptosis of MV-4-11 cells in a dose-dependent manner[1].BRD4 Inhibitor-18 (0.5 and 5 μM; 4 hours) inhibits the expression of c-Myc protein in a dose-dependent manner[1]. Cell Proliferation Assay Cell Line:
Name	BRD4 Inhibitor-18
CAS	2451219-73-9
Formula	C26H26ClN3O3S
Molar Mass	496.02
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.

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