| Bioactivity | BRD-K20733377 is an inhibitor for Bcl-2, and exhibits selective cytotoxicity against senescent cells, that inhibits the viability of Etoposide (HY-13629)-induced IMR-90 senescent cell with an IC50 of 10.7 μM. BRD-K20733377 reduces the mRNA expression of aging-related genes p16, p21 and KI67 in aged mouse model[1]. |
| CAS | 452350-43-5 |
| Formula | C23H18N4O3S |
| Molar Mass | 430.48 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Wong F, et al., Discovering small-molecule senolytics with deep neural networks. Nat Aging. 2023 Jun;3(6):734-750. |
BRD-K20733377
CAS: 452350-43-5 F: C23H18N4O3S W: 430.48
BRD-K20733377 is an inhibitor for Bcl-2, and exhibits selective cytotoxicity against senescent cells, that inhibits the
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