| Bioactivity | BR-cpd7 is a PROTAC degrader for fibroblast growth factor receptor FGFR1/2 with DC50 of 10 nM. BR-cpd7 arrests cell cycle, inhibits proliferations of FGFR1/2 aberrant activated tumor cells. (Pink: ligand for target protein FGFR-IN-12 (HY-160013); Black: linker; Blue: ligand for E3 ligase Thalidomide-NH-CH2-COOH (HY-131717))[1] |
| Formula | C44H47Cl2N11O8 |
| Molar Mass | 928.82 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Kong Y, et al., A Selective FGFR1/2 PROTAC Degrader with Antitumor Activity. Mol Cancer Ther. 2024 Jun 10:OF1-OF11. |