| Bioactivity | BPU-11 is a hyperpolarization-activated cyclic nucleotide-gated (HCN) C-linker pocket (CLP) HCN4 CLP ligand. BPU-11 can be used for the research of congenital immune disease[1]. | ||||||||||||
| Invitro | BPU-11 (100 μM) 消除了 HCN4 cAMP 诱导的 V1/2 位移，k1/2 为 0.42 μM[1]。BPU (100 和 200 μM) 是 HCN4 亚型特异性的，对 HEK293T 细胞中表达的 HCN2 通道无影响[1]。 | ||||||||||||
| Name | BPU-11 | ||||||||||||
| CAS | 909664-41-1 | ||||||||||||
| Formula | C32H31N5O | ||||||||||||
| Molar Mass | 501.62 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Lolicato M, et al. Cyclic dinucleotides bind the C-linker of HCN4 to control channel cAMP responsiveness. Nat Chem Biol. 2014 Jun;10(6):457-62. |