| Bioactivity | BPIPP is a guanylyl cyclase type C (GC-C) and adenylyl cyclase inhibitor that can suppress cyclic nucleotide synthesis. BPIPP inhibits chloride-ion transport stimulated by activation of guanylyl or adenylyl cyclases, and has the potential for diarrhea research[1]. |
| Invitro | BPIPP 通过降低完整的 T84 人结直肠癌细胞中的 GC-C 活化来抑制稳定毒素 (STa) 刺激的 cGMP 积累。BPIPP 抑制鸟苷酸环化酶的刺激，包括各种细胞中的 A 型和 B 型以及可溶性异构体。BPIPP 抑制腺苷酸环化酶的刺激，并显著降低百日咳杆菌腺苷酸环化酶毒素和炭疽杆菌水肿毒素的活性。仅在完整细胞中观察到 BPIPP 对环核苷酸合成的影响[1]。BPIPP 抑制鸟苷酸或腺苷酸环化酶激活刺激的氯离子转运，并抑制体内兔肠环模型中 STa 诱导的液体积聚[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> BPIPP 相关抗体: |
| CAS | 325746-94-9 |
| Formula | C22H16BrN3O3 |
| Molar Mass | 450.28 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Alexander Y Kots, et al. Pyridopyrimidine derivatives as inhibitors of cyclic nucleotide synthesis: Application for treatment of diarrhea. Proc Natl Acad Sci U S A. 2008 Jun 17;105(24):8440-5. |