Bioactivity | BODIPY FL Verapamil hydrochloride is a fluorescent dye, it can be used as a molecular probe to label tissues and cells. BODIPY FL Verapamil hydrochloride is a substrate for both ABCB1 and ABCC1[1][2]. |
Invitro | BODIPY FL Verapamil hydrochloride (10 μM) can be incubated with removed tissue in phosphate buffered solution to demonstrate binding site[1].BODIPY FL Verapamil hydrochloride (0-100 nM) inhibits ABCB1 and ABCC1 efflux with loxapine, mometasone, nicardipine, pimozide and verapamil with IC50 values of 1.6-15.6 nM[2]. |
Name | BODIPY FL Verapamil hydrochloride |
CAS | 216571-88-9 |
Formula | C41H56BClF2N4O5 |
Molar Mass | 769.17 |
Transport | Room temperature in continental US; may vary elsewhere. |
Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Reference | [1]. Just S, et al. Histological demonstration of voltage dependent calcium channels on calcitonin gene-related peptide-immunoreactive nerve fibres in the mouse knee joint. Neurosci Lett. 2001 Oct 26;312(3):133-6. [2]. Strouse JJ, et al. Fluorescent substrates for flow cytometric evaluation of efflux inhibition in ABCB1, ABCC1, and ABCG2 transporters. Anal Biochem. 2013 Jun 1;437(1):77-87. |