| Bioactivity | BMT-124110 is a potent, selective AAK1 inhibitor with an IC50 of 0.9 nM. BMT-124110 shows antinociceptive activity. BMT-090605 inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC50s of 17 and 99 nM, respectively[1]. |
| Invitro | BMT-124110 shows a cellular IC50 of 3.2±1.4 nM for AAK1[1]. |
| In Vivo | BMT-124110 is added directly onto the spinal corevd by microiontophoresis, leading to reduction in windup-induced activity in 10 of 14 animals[1]. |
| Name | BMT-124110 |
| CAS | 1679371-59-5 |
| Formula | C21H27N3O3 |
| Molar Mass | 369.46 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Kostich W, et al. Inhibition of AAK1 Kinase as a Novel Therapeutic Approach to Treat Neuropathic Pain. J Pharmacol Exp Ther. 2016 Sep;358(3):371-86. |
BMT-124110
CAS: 1679371-59-5 F: C21H27N3O3 W: 369.46
BMT-124110 is a potent, selective AAK1 inhibitor with an IC50 of 0.9 nM. BMT-124110 shows antinociceptive activity. BMT-
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.