BMT-090605 hydrochloride_product_DataBase

Bioactivity

BMT-090605 hydrochloride is a potent, selective the adapter protein-2 associated kinase 1 (AAK1) inhibitor with an IC50 value of 0.6 nM. BMT-090605 hydrochloride shows antinociceptive activity. BMT-090605 hydrochloride inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC50 values of 45 nM and 60 nM, respectively. BMT-090605 hydrochloride can be used for the research of neuropathic pain[1].

Target

IC50: 0.6 nM (AAK1); 45 nM (BIKE); 60 nM (GAK)

Invitro

BMT-090605 hydrochloride shows AAK1inhibitory activity with an IC50 of 0.63 nM[1].BMT-090605 hydrochloride inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC50 values of 45 nM and 60 nM, respectively[1].

In Vivo

BMT-090605 hydrochloride(intrathecal; 0.3-3 µg/rat) causes antinociception by inhibiting AAK1 in the spinal cord[1]. Animal Model:

Name

BMT-090605 hydrochloride

CAS

2231664-45-0

Formula

C21H25ClN4O2

Molar Mass

400.90

Appearance

Solid

Transport

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Reference

[1]. Kostich W, et al. Inhibition of AAK1 Kinase as a Novel Therapeutic Approach to Treat Neuropathic Pain. J Pharmacol Exp Ther. 2016 Sep;358(3):371-86.

PeptideDB

BMT-090605 hydrochloride

CAS: 2231664-45-0 F: C21H25ClN4O2 W: 400.90