| Bioactivity | BMS-986318 is a potent nonbile acid FXR agonist with EC50s of 53 and 350 nM in the FXR Gal4 and SRC-1 recruitment assays, respectively. BMS-986318 has a suitable ADME profile, and demonstrates efficacy in the mouse bile duct ligation model of liver cholestasis and fibrosis.BMS-986318 can be used for the research of nonalcoholic steatohepatitis[1]. |
| Name | BMS-986318 |
| CAS | 2314378-09-9 |
| Formula | C30H23Cl2F3N4O3 |
| Molar Mass | 615.43 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Joseph Carpenter, et al. Discovery of BMS-986318, a Potent Nonbile Acid FXR Agonist for the Treatment of Nonalcoholic Steatohepatitis. ACS Med Chem Lett. 2021 Aug 5;12(9):1413-1420. |
BMS-986318
CAS: 2314378-09-9 F: C30H23Cl2F3N4O3 W: 615.43
BMS-986318 is a potent nonbile acid FXR agonist with EC50s of 53 and 350 nM in the FXR Gal4 and SRC-1 recruitment assays
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