BMS-823778 hydrochloride

CAS: 1140898-87-8 F: C18H19Cl2N3O W: 364.27

BMS-823778 hydrochloride is a potent, selective and orally active 11β-HSD1 inhibitor with an IC50 of 2.3 nM against hum

Contact QiTai

This product is for research use only, not for human use. We do not sell to patients.

Bioactivity	BMS-823778 hydrochloride is a potent, selective and orally active 11β-HSD1 inhibitor with an IC50 of 2.3 nM against human 11β-HSD1[1].
Target	IC50: 2.3 nM (human 11β-HSD1), 600 nM (mouse 11β-HSD1)Ki: 0.9 nM (human 11β-HSD1), 380 nM (mouse 11β-HSD1)
In Vivo	BMS-823778 (10-100 mg/kg; oral; once) hydrochloride 在饮食诱导肥胖 (DIO) 小鼠中表现出强烈的急性药效学作用 (ED50=34 mg/kg)[1]。 Animal Model:
Name	BMS-823778 hydrochloride
CAS	1140898-87-8
Formula	C18H19Cl2N3O
Molar Mass	364.27
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Li J, et al. Discovery of Clinical Candidate BMS-823778 as an Inhibitor of Human 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD-1). ACS Med Chem Lett. 2018 Nov 13;9(12):1170-1174.