| Bioactivity | BMS-818251 is a potent, small-molecule inhibitor of HIV-1 entry with an EC50 value of 0.019 nM. BMS-818251 shows >10-fold higher potency than BMS-626529 (HY-15440) on a cross-clade panel of 208-HIV-1 strains. BMS-818251 interacts with gp120 residues from the conserved β20-β21 hairpin to improve potency[1]. |
| CAS | 2974489-09-1 |
| Formula | C29H26N6O5S |
| Molar Mass | 570.62 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Lai YT, et al. Lattice engineering enables definition of molecular features allowing for potent small-molecule inhibition of HIV-1 entry. Nat Commun. 2019 Jan 3;10(1):47. |
BMS-818251
CAS: 2974489-09-1 F: C29H26N6O5S W: 570.62
BMS-818251 is a potent, small-molecule inhibitor of HIV-1 entry with an EC50 value of 0.019 nM. BMS-818251 shows >10-fol
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