| Bioactivity | BMS-741672 is a selective and orally active CCR2 antagonist with an IC50 of 1.1 nM. BMS-741672 shows >700-fold selective for CCR2 than CCR5[1]. |
| Invitro | BMS-741672 在体外抑制单核细胞趋化性时表现出 IC50 值为 0.67 nM，并且在猴子和 hCCR2 敲入小鼠的单核细胞趋化性模型中均具有完全活性[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> BMS-741672 相关抗体: |
| In Vivo | 发现 BMS-741672 在大鼠中的口服生物利用度为 51%，t1/2 值为 5.1 小时（IV），在食蟹猴中的口服生物利用度为 46%，t1/2 为 3.2 小时（IV）[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| CAS | 1004757-96-3 |
| Formula | C25H33F3N6O2 |
| Molar Mass | 506.56 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Michael G Yang, et al. Use of a Conformational-Switching Mechanism to Modulate Exposed Polarity: Discovery of CCR2 Antagonist BMS-741672. ACS Med Chem Lett. 2019 Jan 16;10(3):300-305. |
BMS-741672
CAS: 1004757-96-3 F: C25H33F3N6O2 W: 506.56
BMS-741672 is a selective and orally active CCR2 antagonist with an IC50 of 1.1 nM. BMS-741672 shows >700-fold selective
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