| Bioactivity | BMS-681 is an orthosteric antagonist of CC chemokine receptor 2 (CCR2). BMS-681 restricts the movement of the extracellular end of TM6 by stabilizing TM7, a major component of the orthosteric binding site of TM7 and TM6. BMS-681 can be used in the study of inflammatory neurodegenerative diseases and cancer[1]. |
| CAS | 847998-92-9 |
| Formula | C26H36F3N5O |
| Molar Mass | 491.59 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. An X, et al. Revealing the positive binding cooperativity mechanism between the orthosteric and the allosteric antagonists of CCR2 by metadynamics and Gaussian accelerated molecular dynamics simulations[J]. ACS chemical neuroscience, 2020, 11(4): 628-637. |