BMS-605541_product_DataBase

Bioactivity

BMS-605541 is a selective and orally active inhibitor of VEGFR-2 kinase with an IC50 value of 23 nM and Ki value of 49 nM. BMS-605541 inhibits the activity of Flk-1, VEGFR-1 and PDGFR-β with IC50 values of 40 nM, 400 nM and 200 nM, respectively. BMS-605541 can be used for cancer research[1].

Invitro

BMS-605541 (Compound 14) 通过 VEGF 抑制 HUVECs 的生长，IC50 值为 25 nM[1]。

In Vivo

BMS-605541 (12.5-180 mg/kg；一天 1 次或一天 2 次，持续 14 天) 对皮下植入 L2987 和 HCT-116 异种移植物的无胸腺小鼠具有抗肿瘤活性[1]。BMS-605541 的药代动力学 (PK) 参数[1]Species

Name

BMS-605541

CAS

639858-32-5

Formula

C19H17F2N5OS

Molar Mass

401.43

Appearance

Solid

Transport

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Reference

[1]. Borzilleri RM, et al. Discovery and evaluation of N-cyclopropyl- 2,4-difluoro-5-((2-(pyridin-2-ylamino)thiazol-5- ylmethyl)amino)benzamide (BMS-605541), a selective and orally efficacious inhibitor of vascular endothelial growth factor receptor-2. J Med Chem. 2006 Jun 29;49(13):3766-9.

PeptideDB

BMS-605541

CAS: 639858-32-5 F: C19H17F2N5OS W: 401.43