| Bioactivity | BMS-502 (Compound 22) is a potent dual inhibitor of diacylglycerol kinase (DGK) α and ζ with IC50 of 4.6 nM and 2.1 nM. BMS-502 enhanced T cell immune responses in mice. BMS-502 can be used in tumor immunity related research[1]. |
| Target | IC50: 4.6 nM (DGK α), 2.1nM (DGK ζ). |
| Invitro | 在小鼠细胞毒性 T 细胞 IFNγ 试验 (mCTC) 中测得的 BMS-502 EC50 值为 340 nM[1]。 |
| In Vivo | BMS-502 (Compound 22) （0-10mg/kg； 口服； 24 小时） 在小鼠 OT-1 模型中表现出剂量依赖性免疫刺激作用[1]。 C57 小鼠中药代动力学分析[1]Route |
| Name | BMS-502 |
| CAS | 2407854-18-4 |
| Formula | C27H22F2N6O3 |
| Molar Mass | 516.50 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Chupak L, et al. Discovery of Potent, Dual-Inhibitors of Diacylglycerol Kinases Alpha and Zeta Guided by Phenotypic Optimization. ACS Med Chem Lett. 2023 Jun 12;14(7):929-935. |