| Bioactivity | BMS-466442 is a potent and selective inhibitor of asc-1 (alanine serine cysteine transporter-1), with an IC50 of 11 nM. BMS-466442 inhibits [3H] D-serine uptake into rat brain synaptosomes, with an IC50 of 400 nM. BMS-466442 can be used for schizophrenia research[1][2]. |
| Target | IC50: 1 nM (asc-1), 420 nM (dopamine transporter), 6.1 μM (Adrenergic α1D receptor), ≥10 μM (LAT-2), ≥10 μM (ASCT-2) |
| Invitro | BMS-466442 dose-dependently inhibits asc-1 activity in human asc-1 expressing cells and primary cultures with IC50 values of 36.8 ± 11.6 nM and 19.7 ± 6.7 nM, respectively[1]. |
| Name | BMS-466442 |
| CAS | 1598424-76-0 |
| Formula | C31H30N4O5 |
| Molar Mass | 538.59 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Brown JM, et al. In vitro Characterization of a small molecule inhibitor of the alanine serine cysteine transporter -1 (SLC7A10). J Neurochem. 2014 Apr;129(2):275-83. [2]. Torrecillas IR, et al. Inhibition of the Alanine-Serine-Cysteine-1 Transporter by BMS-466442. ACS Chem Neurosci. 2019 May 15;10(5):2510-2517. |
BMS-466442
CAS: 1598424-76-0 F: C31H30N4O5 W: 538.59
BMS-466442 is a potent and selective inhibitor of asc-1 (alanine serine cysteine transporter-1), with an IC50 of 11 nM.
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