| Bioactivity | BMS-433771 is a potent orally active inhibitor of respiratory syncytial virus (RSV). BMS-433771 is active against both A and B groups of RSV, with an average EC50 of 20 nM. BMS-433771 can be used for the research of respiratory tract disease[1][2]. | ||||||||||||
| Target | EC50: 20 nM (RSV) | ||||||||||||
| Invitro | BMS-433771 has inhibitory against both A and B groups of RSV, with an average EC50 of 20 nM[1].BMS-433771 can inhibit viral F protein-induced membrane fusion[1]. | ||||||||||||
| In Vivo | BMS-433771 (p.o.; 1-200 mg/kg; single or bid 4 days) shows prophylactic efficacy via oral dosing，but has considerable pharmacodynamic differences between the two rodent models[2]. Animal Model: | ||||||||||||
| Name | BMS-433771 | ||||||||||||
| CAS | 543700-68-1 | ||||||||||||
| Formula | C21H23N5O2 | ||||||||||||
| Molar Mass | 377.44 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Christopher Cianci, et al. Antiviral activity and molecular mechanism of an orally active respiratory syncytial virus fusion inhibitor. J Antimicrob Chemother [2]. Christopher Cianci, et al. Oral efficacy of a respiratory syncytial virus inhibitor in rodent models of infection. Antimicrob Agents Chemother. 2004 Jul;48(7):2448-54. |
BMS-433771
CAS: 543700-68-1 F: C21H23N5O2 W: 377.44
BMS-433771 is a potent orally active inhibitor of respiratory syncytial virus (RSV). BMS-433771 is active against both A
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