BMS-284640

CAS: 230640-88-7 F: C15H19N3O2 W: 273.33

BMS-250749 is a fluoroglycosyl-3,9-difluoroindolcarbazole topoisomerase I inhibitor with potent in vitro and in vivo pre

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Bioactivity	BMS-250749 is a fluoroglycosyl-3,9-difluoroindolcarbazole topoisomerase I inhibitor with potent in vitro and in vivo preclinical properties. BMS-250749 exhibits potent topoisomerase I activity, cytotoxicity, and selectivity. BMS-250749 exhibits broad-spectrum antitumor activity superior to CPT-11 in certain preclinical xenograft models. BMS-250749 shows curative antitumor activity against Lewis lung cancer. BMS-250749 is the lead clinical candidate in a series of fluoroglycosylated fluoroindolecarbazoles[1].
Target	Topoisomerase I
CAS	230640-88-7
Formula	C15H19N3O2
Molar Mass	273.33
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.