BMS-189664_product_DataBase

Bioactivity	BMS-189664 is a potent, selective, and orally active reversible inhibitor of a-thrombin, with an IC50 of 0.046 μM. BMS-189664 can be used for arterial and venous thrombosis research[1].
In Vivo	BMS-189664 可有效保护小鼠免于凝血酶诱发的死亡[1]。BMS-189664 (0.2 mg/kg，静脉注射)可抑制食蟹猴模型中的动脉血栓形成[1]。BMS-189664 (以 9、25 和 100 mg/kg/min 输注 1 小时，达到 0.5、2 和 6 mg/kg)可抑制食蟹猴模型中的静脉血栓形成[1]。根据口服和静脉给药后剂量标准化的 AUC，BMS-189664 的口服生物利用度在狗和猴子中分别为 15% 和 17%[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.
CAS	162166-80-5
Formula	C22H34N6O4S
Molar Mass	478.61
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Das J, et al. Molecular design and structure--activity relationships leading to the potent, selective, and orally active thrombin active site inhibitor BMS-189664. Bioorg Med Chem Lett. 2002 Jan 7;12(1):45-9.

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