BMS 182874 hydrochloride_product_DataBase

Bioactivity	BMS 182874 hydrochloride is an orallyactive, highly selective endothelin receptor (ETA receptor) antagonist, with IC50 value of 0.150 μM, Ki of 0.055 μM. BMS 182874 hydrochloride reduces the arterial pressure of Deoxycorticosterone acetate (HY-B1472) induced hypertension model in rats, and can be used for cardiovascular disease research[1].
Invitro	BMS 182874 hydrochloride (dimethyla minoanalogue 11) 是 ETA 诱导的细胞内 Ca2+ 增加的有效的功能拮抗剂，在 vsm -A10 细胞中的 IC50 值为 0.150 μM, Ki 值为 0.055 μM，在兔颈动脉环中 KB 值为 0.520 μM[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> BMS 182874 hydrochloride 相关抗体:
In Vivo	BMS 182874 hydrochloride (100 μM/kg；单次口服) 使动脉血压从对照水平缓慢下降 25%。给药 12 和 24 小时后，动脉血压仍比对照水平低 12%[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.
CAS	1215703-04-0
Formula	C17H20ClN3O3S
Molar Mass	381.88
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Abdullaha M, et.al. Methoxy-naphthyl-Linked N-Benzyl Pyridinium Styryls as Dual Cholinesterase Inhibitors: Design, Synthesis, Biological Evaluation, and Structure-Activity Relationship. ACS Omega. 2023 May 9;8(20):17591-17608.

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