| Bioactivity | BMP agonist 1 (compound 2 b) is a small-molecule agonist of bone morphogenic protein (BMP). BMP induces C2C12 cell differentiation with BMP and highly depends on active BMP signaling. BMP agonist 1 inhibits GSK3β, increases β-catenin signaling and synergistically regulates Id2and Id3 expression. BMP agonist 1 is used in diseases and defects of the skeleton research[1]. |
| Invitro | BMP agonist 1 (0.01-10 μM，24 小时) 减少了 C2C12 细胞的增殖[1]。BMP agonist 1 (0.5-1 μM，2 小时) 抑制了 C2C12 细胞中的 GSK3β，增加了 β-catenin 的信号表达，协同调节了 Id2 和 Id3 的表达[1]。BMP agonist 1 (0.01-10 μM) 在与 Chromenone 1 (0.5−1 μM) 联用时，有效促进了 C2C12 细胞中典型BMP增强因子 Chromenone 1 (HY-143891) 的成骨分化 (Alp 活性)[1]。 0 --> BMP agonist 1 相关抗体: Cell Proliferation Assay[1] Cell Line: |
| Name | BMP agonist 1 |
| Formula | C21H16N2O6 |
| Molar Mass | 392.36 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Riege D, et al. Identification of Maleimide-Fused Carbazoles as Novel Noncanonical Bone Morphogenetic Protein Synergizers. ACS Pharmacol Transl Sci. 2023 Jul 19;6(8):1207-1220. |