| Bioactivity | BM-962 (Compound 31) is a potent small-molecule inhibitor of Bcl-2 with an IC50 value of 4 nM (Ki=0.8 nM) and Bcl-xL with an IC50 value of 3.9 nM (Ki <1 nM). BM-962 inhibits the cell growth in H1417 and H146 cell lines with IC50 values of 9 and 13 nM, respectively. BM-962 is promising for research of cancers[1][2]. | ||||||||||||
| CAS | 1391107-57-5 | ||||||||||||
| Formula | C53H58ClF3N6O7S3 | ||||||||||||
| Molar Mass | 1079.71 | ||||||||||||
| Appearance | 固体 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Chen J, et al. Structure-based discovery of BM-957 as a potent small-molecule inhibitor of Bcl-2 and Bcl-xL capable of achieving complete tumor regression. J Med Chem. 2012 Oct 11;55(19):8502-14. [2]. Wang SM, et al. Bcl-2/Bcl-xL inhibitors and therapeutic methods using the same. US20120189539. 2012 July 26. |
BM-962
CAS: 1391107-57-5 F: C53H58ClF3N6O7S3 W: 1079.71
BM-962 (Compound 31) is a potent small-molecule inhibitor of Bcl-2 with an IC50 value of 4 nM (Ki=0.8 nM) and Bcl-xL wit
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