| Bioactivity | BLT2 antagonist-1 (compound 15b) is a selective BLT2 antagonist that inhibits the chemotaxis of CHO-BLT2 cells with an IC50 of 224 nM. BLT2 antagonist-1 does not inhibits the chemotaxis of CHO-BLT1 cells. BLT2 antagonist-1 also inhibits the binding of LTB4 and BLT2 with a Ki value of 132 nM. BLT2 antagonist-1 can be used for the research of the inflammatory airway diseases such as asthma and chronic obstructive pulmonary disease[1]. |
| Name | BLT2 antagonist-1 |
| CAS | 2069220-61-5 |
| Formula | C26H26FNO4 |
| Molar Mass | 435.49 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Hyejun Park, et al. Discovery of a novel BLT2 antagonist for the treatment of inflammatory airway diseases. Eur J Med Chem. 2023 Oct 7:261:115864. |
BLT2 antagonist-1
CAS: 2069220-61-5 F: C26H26FNO4 W: 435.49
BLT2 antagonist-1 (compound 15b) is a selective BLT2 antagonist that inhibits the chemotaxis of CHO-BLT2 cells with an I
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