| Bioactivity | BLM-IN-1 is an effective bloom syndrome protein (BLM) inhibitor. BLM-IN-1 has a high binding affinity with a KD valueof 1.81 μM. BLM-IN-1 has good inhibitory effect for BLM with an IC50 value of 0.95 μM. BLM-IN-1 can induce cell apoptosis. BLM-IN-1can be used for the research of DNA damage and cancer[1]. | ||||||||||||
| Invitro | BLM-IN-1 (compound 29) has a strong BLM binding with a KD of 1.81 μM[1].BLM-IN-1 can inhibit BLM with an IC50 of 0.95 μM[1].BLM-IN-1 (1.0 μM) inhibits the unwinding activity of BLM but also disrupt the BLM binding to DNA[1].BLM-IN-1 (0-1.0 μM) regulates the homologous recombination by disrupting the recruitment of BLM to DSB sites[1].BLM-IN-1 (1.0, 2.0 μM; 48 h) induces DNA damage response and apoptosis[1].BLM-IN-1 (0.1, 1.0, 2.0 μM; 48 h) induces proliferation arrest and synthetic interaction[1]. Western Blot Analysissup>[1] Cell Line: | ||||||||||||
| Name | BLM-IN-1 | ||||||||||||
| CAS | 2056014-40-3 | ||||||||||||
| Formula | C28H35FN4O | ||||||||||||
| Molar Mass | 462.60 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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BLM-IN-1
CAS: 2056014-40-3 F: C28H35FN4O W: 462.60
BLM-IN-1 is an effective bloom syndrome protein (BLM) inhibitor. BLM-IN-1 has a high binding affinity with a KD valueof
Data collection：peptidedb@qq.com
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