BK50164_product_DataBase

Bioactivity	BK50164 is a potent CD73 inhibitor with an IC50 value of 13.089 µM. BK50164 binds to CD99 with a KD value of 1.5 µM. BK50164 shows antiproliferative activity. BK50164 induced Apoptosis and cell cycle arrest at Sub-G1 phase[1].
Target	IC50: 13.089 µM (CD73)
Invitro	BK50164 (0-400 µM；48 小时) 显示抗增殖活性，对 A4573, TC-32, TC-71, Saos-2, U-2 OS 细胞的 IC50 值分别为35.8, 34.28, 5.17, ≥400, ≥400 µM[2]。BK50164 (4-16 µM; 48 h) 诱导细胞凋亡和细胞周期停滞在 Sub-G1 期[2]。 Cell Viability Assay[2] Cell Line:
Name	BK50164
CAS	2204291-78-9
Formula	C13H13ClFN5O7
Molar Mass	405.72
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Roland Joseph Billedeau, et al. Ectonucleotidase inhibitors and methods of use thereof. WO2018119284A1. [2]. Balaraman K, et al. Design, synthesis and biological evaluation of Nucleosidic CD99 inhibitors that selectively reduce Ewing sarcoma viability. Eur J Med Chem. 2023 May 5;251:115244.

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