| Bioactivity | BI 3231 is a potent and selective hydroxysteroid 17ß-dehydrogenase 13 (HSD17B13) inhibitor, with IC50s of 1 and 13 nM for hHSD17B13 and mHSD17B13, respectively. BI 3231 has the potential for the research of nonalcoholic steatohepatitis (NASH) and other liver diseases[1]. | |||||||||
| Target | hydroxysteroid 17ß-dehydrogenase 13 (HSD17B13) | |||||||||
| Invitro | BI 3231 在肝微粒体中表现出高代谢稳定性，在肝细胞中表现出中等代谢稳定性[1]。 | |||||||||
| In Vivo | BI 3231 从血浆中迅速清除，但在 48 h 内仍保持相当大的肝脏暴露[1]。 | |||||||||
| Name | BI‑3231 | |||||||||
| CAS | 2894848-07-6 | |||||||||
| Formula | C16H14F2N4O3S | |||||||||
| Molar Mass | 380.37 | |||||||||
| Appearance | Solid | |||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
| Storage |
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| Reference | [1]. Thamm S, et, al. Discovery of a Novel Potent and Selective HSD17B13 Inhibitor, BI-3231, a Well-Characterized Chemical Probe Available for Open Science. J Med Chem. 2023 Feb 2. |
BI‑3231
CAS: 2894848-07-6 F: C16H14F2N4O3S W: 380.37
BI 3231 is a potent and selective hydroxysteroid 17ß-dehydrogenase 13 (HSD17B13) inhibitor, with IC50s of 1 and 13 nM f
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