BIX-01294 hydrochloride hydrate_product_DataBase

Bioactivity	BIX-01294 hydrochloride hydrate is a histone-lysine methyltransferase (HMTase) inhibitor, which selective inhibits the G9aHMTase with IC50 of 1.7 μM, reduces histone-3 lysine (9) methylation (H3K9me), induces autophagy and apoptosis in human glioma cells[1][2].
Invitro	BIX-01294 hydrochloride hydrate (1–10 μM) 诱导 LN18 胶质瘤细胞自噬和凋亡，降低细胞活力[1]。BIX-01294 hydrochloride hydrate (1–10 μM) 上调自噬相关基因 LC3B、WIPI1 的水平，下调分化相关基因 GFAP、TUBB3，使胶质瘤干样细胞 (GSC) 发生自噬依赖性分化[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> BIX-01294 hydrochloride hydrate 相关抗体: Cell Viability Assay[1] Cell Line:
CAS	1808255-64-2
Formula	C28H38N6O2.3ClH.xH2O
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Ciechomska IA, et al., BIX01294, an inhibitor of histone methyltransferase, induces autophagy-dependent differentiation of glioma stem-like cells. Sci Rep. 2016 Dec 9;6:38723. [2]. Kubicek S, O'Sullivan RJ, August EM, Hickey ER, Zhang Q, Teodoro ML, Rea S, Mechtler K, Kowalski JA, Homon CA, Kelly TA, Jenuwein T. Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase. Mol Cell. 2007 Feb 9;25(3):473-81.

PeptideDB