| Bioactivity | BIM5078 is a hepatocyte nuclear factor 4α (HNF4α) antagonist that can inhibit the expression of known HNF4α target genes. BIM5078 represses insulin promoter activity through HNF4α antagonism. BIM5078 can be used for the research of cancer and diabetes[1]. |
| Target | hepatocyte nuclear factor 4α (HNF4α) |
| Invitro | BIM5078 (0.63-5 μM；48 h) 抑制内源性胰岛素在 T6PNE 细胞中的表达，IC50 值为 930 nM[1]。 BIM5078 (2.5-10 μM；5-48 h) 在 HepG2 细胞中抑制 HNF4α 基因表达[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> BIM5078 相关抗体: |
| CAS | 337506-43-1 |
| Formula | C14H10ClN3O4S |
| Molar Mass | 351.76 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Kiselyuk A, et al. HNF4α antagonists discovered by a high-throughput screen for modulators of the human insulin promoter. Chem Biol. 2012 Jul 27;19(7):806-18. |