| Bioactivity | BIIL-260 hydrochloride is a potent and long-acting orally active leukotriene B(4) receptor LTB4 antagonist, with anti-inflammatory activity. BIIL-260 hydrochloride interacts with the LTB4 receptor in a saturable, reversible, and competitive manner, has high affinity to the LTB4 receptor on isolated human neutrophil cell membranes with Ki values of 1.7 nM[1]. |
| Target | Ki: 1.7 nM (LTB4 receptor) |
| Invitro | BIIL-260 hydrochloride potently inhibits LTB4-induced intracellular Ca2+ release in human neutrophils with IC50 value of 0.82 nM |
| Name | BIIL-260 hydrochloride |
| CAS | 192581-24-1 |
| Formula | C30H31ClN2O3 |
| Molar Mass | 503.03 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
| Reference | [1]. Birke FW, et al. In vitro and in vivo pharmacological characterization of BIIL 284, a novel and potent leukotriene B(4) receptor antagonist. J Pharmacol Exp Ther. 2001 Apr;297(1):458-66. |
BIIL-260 hydrochloride
CAS: 192581-24-1 F: C30H31ClN2O3 W: 503.03
BIIL-260 hydrochloride is a potent and long-acting orally active leukotriene B(4) receptor LTB4 antagonist, with anti-in
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