| Bioactivity | BIBP3226 TFA is a potent and selective neuropeptide Y Y1 (NPY Y1) and neuropeptide FF (NPFF) receptor antagonist, with Kis of 1.1, 79, and 108 nM for rNPY Y1, hNPFF2, and rNPFF, respectively. BIBP3226 TFA displays anxiogenic-like effect[1][2]. | ||||||
| In Vivo | BIBP3226 (0.5, 5 μg; i.c.v.) induces an anxiogenic-like effect at the higher dose[1]. Animal Model: | ||||||
| Name | BIBP3226 TFA | ||||||
| CAS | 1068148-47-9 | ||||||
| Formula | C29H32F3N5O5 | ||||||
| Molar Mass | 587.59 | ||||||
| Appearance | Solid | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Sealed storage, away from moisture and light
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) |
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| Reference | [1]. Mollereau C, et al. Agonist and antagonist activities on human NPFF(2) receptors of the NPY ligands GR231118 and BIBP3226. Br J Pharmacol. 2001 May;133(1):1-4. [2]. Kask A, et al. Anxiogenic-like effect of the neuropeptide Y Y1 receptor antagonist BIBP3226: antagonism with diazepam. Eur J Pharmacol. 1996 Dec 19;317(2-3):R3-4. |
BIBP3226 TFA
CAS: 1068148-47-9 F: C29H32F3N5O5 W: 587.59
BIBP3226 TFA is a potent and selective neuropeptide Y Y1 (NPY Y1) and neuropeptide FF (NPFF) receptor antagonist, with K
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