BI-685509_product_DataBase

Bioactivity	BI-685509 is a potent and orally active sGC activator. BI-685509 restores cyclic guanosine monophosphate (cGMP) and improves functionality of nitric oxide (NO) pathways. BI-685509 can be used in research of chronic kidney disease (CKD) and diabetic kidney disease (DKD)[1].
Invitro	BI 685509 在用血红素氧化剂 ODQ (HY-101255) 处理的人和大鼠富含血小板的血浆中增加 cGMP，EC50 值分别为 467 nM 和 304 nM[1]。
In Vivo	BI 685509 (1, 3, 10, 30 mg/kg; p.o.) 与 Enalapril (HY-B0331) 共同给药以剂量依赖性方式降低蛋白尿和肾小球硬化的发生率[1]。BI 685509 (30 mg/kg; p.o.) 减少大鼠单侧输尿管梗阻 (UUO) 模型中的肾小管间质纤维化[1]。 Animal Model:
Name	BI-685509
CAS	1579514-06-9
Formula	C34H38N4O5
Molar Mass	582.69
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Reinhart GA, et, al. The Novel, Clinical-Stage Soluble Guanylate Cyclase Activator BI 685509 Protects from Disease Progression in Models of Renal Injury and Disease. J Pharmacol Exp Ther. 2023 Mar;384(3):382-392.

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