| Bioactivity | BGT1-IN-1 (compound 9) is a potent BGT1 inhibitor with IC50 value of 13.9, 58.3 µM for hBGT1, GAT3, respectively. BGT1-IN-1 shows no cytotoxic. BGT1-IN-1 shows neuroprotective activity[1]. |
| Target | IC50: 33.9 µM (BGT1); 64.2 µM (E52A); >1000 µM (E52Y); 73.5 µM (Q299L) |
| In Vivo | IC50: 13.9 µM (hBGT1); 58.3 µM (GAT3)[1] MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| CAS | 406947-32-8 |
| Formula | C6H9NO2 |
| Molar Mass | 127.14 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Łątka K, et al. Rational Search for Betaine/GABA Transporter 1 Inhibitors─In Vitro Evaluation of Selected Hit Compound. ACS Chem Neurosci. 2024 Oct 19. |