| Bioactivity | BG47 is a prototypical histone deacetylases HDAC1 and HDAC2 selective, optoepigenetic probe. BG47 can bind to and competitively inhibits the deacetylase activity of HDAC targets upon a light-induced trans-to-cis isomerization, and increases Histone Methyltransferase H3K9 acetylation. BG47 can be used for neurological disease research[1]. |
| Invitro | BG47 (10 μM，16 小时) 在光存在 (开 25 ms/关 75 ms) 情况下使人神经元前体细胞 (NPCs) 中 H3K9 乙酰化升高，并显著上调前颗粒蛋白 (PGRN) 表达[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> BG47 相关抗体: Immunofluorescence[1] Cell Line: |
| CAS | 1628784-54-2 |
| Formula | C25H22N4O2S |
| Molar Mass | 442.53 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Reis SA, et al. Light-controlled modulation of gene expression by chemical optoepigenetic probes. Nat Chem Biol. 2016 May;12(5):317-23. |