| Bioactivity | BG-136 is an innate immune stimulant isolated from Durvillaea Antarctica that can simultaneously stimulate the activation of both innate and adaptive immune cells in the tumor microenvironment (TME), exerting a broad-spectrum antitumor effect[1]. |
| In Vivo | BG136 (0.3 mg/kg, i.v. twice a week) 能够在 C57BL/6 J 小鼠结直肠癌 (CRC) 细胞系 MC38 同种异体肿瘤模型中体内抑制肿瘤生长，且未观察到体重减轻[1]。BG136 (0.3 mg/kg, i.v. twice a week) 在 MC38 同源肿瘤模型中与抗 PD1 抗体 (200 μg per mouse, i.v. once a week) 联合使用，能增强抗 PD1 抗体肿瘤抑制作用，更有效地抑制肿瘤生长[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| Molar Mass | 4000-7000 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Song Q, et al. A β-1, 3/1, 6-glucan enhances anti-tumor effects of PD1 antibody by reprogramming tumor microenvironment[J]. International Journal of Biological Macromolecules, 2024, 279: 134660. |