| Bioactivity | BET-IN-26 (compound 13a) is a potent, selective and orally active BD1 inhibitor with IC50 values of 0.0055, 9.0 µM for BD1, BD2, respectively. BET-IN-26 decreases LPS (HY-D1056) induced serum levels of IL-6 and MCP-1[1]. |
| In Vivo | BET-IN-26 (compound 13a) (10, 100 mg/kg; p.o.) 以剂量依赖性方式降低小鼠中 LPS (HY-D1056) 诱导的血清 IL-6 和 MCP-1 水平[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| Formula | C26H36N6O2S |
| Molar Mass | 496.67 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Hagihara S, et al. Discovery of a potent orally available pyrazolopyridone derivative as a novel selective bromodomain and extra-terminal domain (BET)-first bromodomain (BD1) inhibitor. Bioorg Med Chem Lett. 2024 Sep 1;109:129849. |