| Bioactivity | BChE-IN-31 (Compound 14d) is a selective BChE inhibitor with an IC50 of 65 nM. BChE-IN-31 inhibits the self-induced aggregation of neurotoxic amyloid-β (Aβ) peptide[1]. |
| Invitro | BChE-IN-31 (0-20 μM, 24 h) 在 5 μM 剂量浓度下对 SH-SY5Y 细胞中 NMDA (HY-17551) 诱导的细胞毒性和 H2O2 诱导的氧化反应具有保护作用[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> BChE-IN-31 相关抗体: Cell Viability Assay[1] Cell Line: |
| Formula | C31H42N4O |
| Molar Mass | 486.69 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Samarelli F, et al., Novel 6-alkyl-bridged 4-arylalkylpiperazin-1-yl derivatives of azepino [4, 3-b] indol-1 (2H)-one as potent BChE-selective inhibitors showing protective effects against neurodegenerative insults[J]. European Journal of Medicinal Chemistry, 2024: 116353. |