| Bioactivity | BCX 1470 inhibits the esterolytic activity of factor D (IC50=96 nM) and C1s (IC50=1.6 nM), 3.4- and 200-fold better, respectively, than that of trypsin. |
| Target | IC50: 96 nM (Factor D); 1.6 nM (C1s); 326 nM (Trypsin) |
| Invitro | BCX 1470 is serine protease inhibitor. BCX 1470 blocks the esterolytic and hemolytic activities of the complement enzymes Cls and factor D in vitro, also blocked development of RPA-induced edema in the rat. |
| Name | BCX 1470 |
| CAS | 217099-43-9 |
| Formula | C14H10N2O2S2 |
| Molar Mass | 302.37 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Szalai, Alexander J.; Digerness, Stanley B.; et al.; The Arthus Reaction in Rodents: Species-Specific Requirement of ComplementJournal of Immunology, 2000, 164, 463-468 |
BCX 1470
CAS: 217099-43-9 F: C14H10N2O2S2 W: 302.37
BCX 1470 inhibits the esterolytic activity of factor D (IC50=96 nM) and C1s (IC50=1.6 nM), 3.4- and 200-fold better, res
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