| Bioactivity | BC11-38 is a potent, selective, and biologically active PDE11 inhibitor, with IC50s of 0.28 µM and >100 µM for PDE11 and PDE1-10, respectively. BC11-38 elevates cAMP levels, PKA-mediated ATF-1 phosphorylation, and cortisol production in H295R cells[1]. |
| Invitro | BC11-38 (20 μM; hours) elevate cAMP levels in H295R adrenocortical cells[1]. |
| Name | BC11-38 |
| CAS | 686770-80-9 |
| Formula | C15H16N2OS2 |
| Molar Mass | 304.43 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | -20°C, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen) |
| Reference | [1]. Ceyhan O, et al. Identification of biologically active PDE11-selective inhibitors using a yeast-based high-throughput screen. Chem Biol. 2012;19(1):155-163. |