| Bioactivity | BC-7013 is a novel semi-synthetic pleuromutilin derivative. BC-7013 has excellent activity against Gram-positive pathogenic bacteria. BC-7013 exhibits potent antibacterial properties against both Staphylococcus, Streptococcus and penicillin-resistant Streptococcus pneumoniae. BC-7013 has activity against Gram-positive pathogenic bacteria, BC-7013 is useful in the research of acute bacterial skin and skin structure infection (ABSSSI)[1]. |
| Target | MIC50: 0.015µg/mL (303 tested S. aureus isolates) |
| Invitro | BC-7013 对 303 株金黄色葡萄球菌有很强的抑制活性，MIC50 值为 0.015 µg/mL[2]。BC-7013 对 A 组链球菌和 B 组链球菌表现出强大的活性，MIC90 值分别为 0.03 µg/mL 和 0.06 µg/mL[2]。 |
| Name | BC-7013 |
| CAS | 1028291-66-8 |
| Formula | C29H40O5S |
| Molar Mass | 500.69 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) |
| Reference | [1]. Shang R, et al. Efficient antibacterial agents: a review of the synthesis, biological evaluation and mechanism of pleuromutilin derivatives. Curr Top Med Chem. 2013;13(24):3013-25. [2]. Biedenbach D J, et al. In vitro antibacterial spectrum of BC-7013, a novel pleuromutilin derivative for topical use in humans. Interscience Conference on Antimicrobial Agents and Chemotherapy. 2009, 49: 199 |