| Bioactivity | BBMP is a permeability transition pore (PTP) inhibitor. BBMP prevents Ca2+-induced permeability transition and mitochondrial depolarization. BBMP possess potential for the neurodegenerative disorders research[1]. |
| Invitro | BBMP 在肿胀和膜电位测定中均有效，pIC50 值分别为 5.5 和 5.6。BBMP 剂量依赖性地防止小脑颗粒神经元中 KCl 25/5 mM 转移和血清剥夺引起的 DNA 碎片化，pIC50 为 5.7。在 10 和 100 μM 时观察到的分离线粒体中 PTP 介导的细胞色素 c 释放的抑制可能解释了其体外神经保护特性[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> BBMP 相关抗体: |
| CAS | 97120-13-3 |
| Formula | C12H11BrN2O3S |
| Molar Mass | 343.20 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Bruno Fuks, et al. In vitro properties of 5-(benzylsulfonyl)-4-bromo-2-methyl-3(2H)-pyridazinone: a novel permeability transition pore inhibitor. Eur J Pharmacol. 2005 Sep 5;519(1-2):24-30. |