| Bioactivity | BAY-771, a structurally close pyrimidinedione, is a chemical probe with good lead-like properties and high permeability in Caco-2 cells (no hint of efflux). BAY-771 shows very weak inhibitory activity in the BCAT1 biochemical assay and no activity in BCAT2. BAY-771 can be used as a negative control of HY-148242 BAY-069. BAY-771 can be used for the research of tumor metabolism[1]. |
| Name | BAY-771 |
| CAS | 2771756-82-0 |
| Formula | C22H15F3N2O3 |
| Molar Mass | 412.36 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Günther J, et al. BAY-069, a Novel (Trifluoromethyl)pyrimidinedione-Based BCAT1/2 Inhibitor and Chemical Probe. J Med Chem. 2022 Nov 10;65(21):14366-14390. |
BAY-771
CAS: 2771756-82-0 F: C22H15F3N2O3 W: 412.36
BAY-771, a structurally close pyrimidinedione, is a chemical probe with good lead-like properties and high permeability
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