| Bioactivity | BAY-524 is a potent Bub1 kinase inhibitor. BAY-524 inhibits the recombinant catalytic domain of human Bub1 with an IC50 of 450 nM. BAY-524 can be used for the research of anti-cancer in combination with other agents[1]. | ||||||||||||
| Target | IC50: 450 nM (human Bub1) | ||||||||||||
| Invitro | BAY-524 inhibits the recombinant catalytic domain of human Bub1 with an IC50 of 450 nM[1].BAY-524 (7-10 μM or 0-30 μM; 14 h or 1 h) specifically inhibit Bub1 kinase[1].BAY-524 (7 μM , 12 h or 7 μM, 12 μM, 3 h) affects Sgo1 and Sgo2 localization and chromatid cohesion in cells[1].BAY-524 (7 μM, 10 μM) affects localization and activity of the CPC[1].BAY-524 (7 μM, 2 h) exerts additive effect on centromere association of CPC[1].BAY-524 (7 μM, 48 h) marginally affects SAC signaling[1].BAY-524 (7 μM, 10 μM) sensitizes cells to low doses of paclitaxel[1]. Western Blot Analysis[1] Cell Line: | ||||||||||||
| Name | BAY-524 | ||||||||||||
| CAS | 1445830-39-6 | ||||||||||||
| Formula | C24H24F2N6O3 | ||||||||||||
| Molar Mass | 482.48 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Baron AP, et al. Probing the catalytic functions of Bub1 kinase using the small molecule inhibitors BAY-320 and BAY-524. Elife. 2016 Feb 17;5. pii: e12187. |
BAY-524
CAS: 1445830-39-6 F: C24H24F2N6O3 W: 482.48
BAY-524 is a potent Bub1 kinase inhibitor. BAY-524 inhibits the recombinant catalytic domain of human Bub1 with an IC50
Data collection：peptidedb@qq.com
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