BAN ORL 24 free base_product_DataBase

Bioactivity	BAN ORL 24 free base is a nociceptin/orphanin FQ (N/OFQ) peptide receptor (NOP) antagonist. BAN ORL 24 free base has antagonistic effect for nociceptin (NOP) receptor with KI value of 0.24 nM in CHO cell. BAN ORL 24 free base can be used for the research of cancer and analgesic[1].
Invitro	BAN ORL 24 是 NOR 和 MOR（阿片受体亚型）拮抗剂，IC50 值分别为 50 μM 和 0.224 μM[2]。 0 --> BAN ORL 24 free base 相关抗体:
In Vivo	BAN ORL 24（10 mg/kg；静脉注射）会减弱 BPRIM97 热镇痛作用的持续时间[3]。
Name	BAN ORL 24 free base
CAS	475150-69-7
Formula	C27H35N3O2
Molar Mass	433.59
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Tao Hou, et al. Label-free cell phenotypic study of opioid receptors and discovery of novel mu opioid ligands from natural products. J Ethnopharmacol [2]. Chao, et al. BPR1M97, a dual mu opioid receptor/nociceptin-orphanin FQ peptide receptor agonist, produces potent antinociceptive effects with safer properties than morphine. Neuropharmacology 166, 107678 (2020). [3]. Fischetti et al (2009) Pharmacological characterization of the nociceptin/orphanin FQ receptor non peptide antagonist compound 24. Eur.J.Pharmacol. 614 50.

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