BACE1-IN-4_product_DataBase

CAS: 2361157-92-6 F: C21H23F2N5O4S2 W: 511.57

BACE1-IN-4 is a potent and highly selective BACE1 inhibitor, with an IC50 of 3.8 nM and a Ki of 1.9 nM, more selective a

This product is for research use only, not for human use. We do not sell to patients.

Bioactivity	BACE1-IN-4 is a potent and highly selective BACE1 inhibitor, with an IC50 of 3.8 nM and a Ki of 1.9 nM, more selective at BACE1 over BACE2. Anti-Alzheimer’s disease[1].
Target	IC50: 3.8 nM (BACE1), 2090 nM (BACE2)Ki: 1.9 nM (BACE1), 1740 nM (BACE2)
Invitro	BACE1-IN-4 (Compound 22) is a potent and highly selective BACE1 inhibitor, with an IC50 of 3.8 nM and a Ki of 1.9 nM, more selective at BACE1 over BACE2 (IC50, 2090 nM; Ki, 1740 nM)[1].
Name	BACE1-IN-4
CAS	2361157-92-6
Formula	C21H23F2N5O4S2
Molar Mass	511.57
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Fujimoto K, et al. Structure-Based Design of Selective β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors: Targeting the Flap to Gain Selectivity over BACE2. J Med Chem. 2019 May 23;62(10):5080-5095.

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