| Bioactivity | BACE-1 inhibitor 2 is a potent and CNS permeable BACE-1 inhibitor with an IC50 of 1.5 nM in BACE-1 enzymatic assay[1]. |
| Target | IC50: 1.5 nM (BACE-1) |
| Invitro | BACE-1 inhibitor 2 inhibits Aβ42 production in human neuroblastoma cell lines with an IC50 of 3.5 nM[1]. |
| Name | BACE-1 inhibitor 2 |
| CAS | 2563970-92-1 |
| Formula | C21H21F4N5O3 |
| Molar Mass | 467.42 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Aldo Peschiulli , et al. 3,3-Difluoro-3,4,5,6-tetrahydropyridin-2-amines: Potent and Permeable BACE-1 Inhibitors. Bioorg Med Chem Lett. 2020 Apr 15;30(8):126999. |
BACE-1 inhibitor 2
CAS: 2563970-92-1 F: C21H21F4N5O3 W: 467.42
BACE-1 inhibitor 2 is a potent and CNS permeable BACE-1 inhibitor with an IC50 of 1.5 nM in BACE-1 enzymatic assay.
Data collection：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.